Autoimmune Channelopathies at Neuromuscular Junction
نویسندگان
چکیده
منابع مشابه
Neuromuscular junction channelopathies: a brief overview.
The neuromuscular junction lacks the protection of the blood-nerve barrier and is vulnerable to antibody-mediated disorders. In myasthenia gravis (MG), 85% of patients have IgG antibodies to acetylcholine receptors (AChRs). About half the remaining patients have IgG antibodies to Muscle Specific Kinase (MuSK), an AChR-associated transmembrane post-synaptic protein concerned in AChR aggregation....
متن کاملAutoimmune disorders of the neuromuscular junction.
The neuromuscular junction lies beyond the protection of the blood-brain barrier and is particularly vulnerable to antibody-mediated attack. In myasthenia gravis, the expression of acetylcholine receptors (AChRs) in the thymus is under the control of the autoimmune regulator protein (AIRE), and polymorphisms in the AChR correlate with early onset of disease. In some 'AChR seronegative' patients...
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channelopathies are disturbances of the cellular membrane channels function. ion channels are actually membrane-bound proteins that perform key functions in virtually all human cells. these channels play pivotal role in the function of excitable tissues such as muscle and nerve. so channelopathies are diverse clinical entities involving many organs and systems (i.e., endocrine, respiratory, gas...
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NATIONAL REVIEW OF 105 OBIOLOGY, VOL. 75 Copyright 2006, Elsev All rights re 0.1016/S0074-7742(06)75006-1 0074-7742/06 II. P hysiological Properties of Transmitter Release III. E xperimental Advantages and Limitations of the Fly NMJ A. C a2þ Measurements B. D ye Loading C. A lternative Measures of Exocytosis IV. H ow Do Vesicles Fuse: Full Fusion or Kiss-and-Run? V. C ore Machinery of Exocytosi...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2019
ISSN: 1664-2295
DOI: 10.3389/fneur.2019.00516